该剧基于作家Arturo Pérez-Reverte的畅销书《La Reina Del Sur》进而改编的。《南方女王》讲述关于女主Teresa Mendoza （Alice Braga饰）的故事，人妻当他的毒贩男盆友在墨西哥意外被谋杀后，人妻女主被迫逃到美国寻求庇护，她与过去的小伙伴一起共同反击杀害他男友并追杀她的贩毒集团头目，然而在这过程中，慢慢的她学会了贩毒行当的“知识”和“谋略”，并渐渐的成为贩毒集团新的老大。Peter Gadiot饰演常規角色James Valdez，是Camila Vargas（Veronica Falcon飾）手下新崛起的人物，对毒品世界十分了解。儘管他會對反抗他的人施加嚴厲的懲罰，但Teresa發現他其實很有自己一套正義感，然後他成为Teresa在美国的重要同盟。Carlos Gomez饰演一个整季的循环角色Javier Acosta，是个在哥伦比亚能发号施令的毒枭。
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回复 :Almost a year has passed since Ellen Parsons left Hewes and Associates. She is now working in the District Attorney's office and is dealing with a fairly important drug case, trying to get a dealer to reveal the identity of his supplier. Patty Hewes is now acting on behalf of a group of investors trying to recover money they had entrusted to Louis Tobin and who, it turns out, was running a Ponzi scheme. With billions of dollars unaccounted for, Patty is trying to find any funds that may have been hidden by the Tobin family. Patty and Ellen have had no contact since her departure but Patty has been reluctant to re-assign her office, convinced that Ellen will return. She even sends her an expensive handbag. Ellen wants nothing to do with her however and when she thinks Patty may be interfering with her drug case, tells her she doesn't need any help. She also tells her that any secrets she may have are perfectly safe. In a flash-forward 6 months into the future, Patty Hewes is in a serious accident when another car broadsides her vehicle in an intersection. The occupant of the other vehicle has fled but it is registered to someone she knows.
回复 :本剧讲述中年男子汤姆·肯德里克（大卫·田纳特饰）原本有着幸福的一家，但妻子和三个女儿却突然被人谋害致死。这件事冲击了原本和平宁静的社区，所有人都变得互相不信任，在案件调查过程中，更多的秘密不断暴露出来...