本故事发生在清朝末年，织田靖王爷（徐连升 饰）为救爱女（朱亚娜 饰）性命，织田不得不病急乱投医，找来了沧州的乡下郎中喜来乐（李保田 饰）。没想到被宫里太医王天和（杜雨露 饰）断为绝症的格格，喜来乐竟用奇招救活。喜来乐本是与世无争，根本不想留在京城这个是非之地，但天意弄人，靖王爷不但用计把他留下，更是把他全家老小和沧州的“一笑堂”搬来京城。从此一向目中无人的王太医就与喜来乐结下了梁子，屡屡对喜来乐暗下毒手。命大的喜来乐不仅每每躲过暗算，更是凭借自创的偏方怪招在京城获得了神医的名号。靖王爷为了让喜来乐安心留在京城，更是把他在沧州的老相好寡妇赛西施（沈傲君 饰）和她的店“食为天”搬到了“一笑堂”的对面。喜来乐爱吃醋的老婆胡氏（梁丽 饰）本就是个不好惹的母老虎，赛西施的到来，更是惹得他们全家每天鸡犬不宁。喜来乐的名气越来越大，甚至得到了皇帝和慈禧的赏识，王太医也加紧了陷害他的脚步，前方等待喜来乐一家人的究竟是什么呢？
高进
回复 :双胞胎姐姐神秘失踪，Khemika（Kwan饰）不得不伪装自己来到Shanon（OM饰）拥有的Lerkwireeya公馆寻找姐姐失踪的真相，从未预想过的结果却令她大吃一惊，几近崩溃。
侯德健
回复 :故事根据日本人气漫画《社畜人》改编，讲述了乐队主唱杨可以（刘畅 饰演）在出道失败后，不幸沦为黑心广告公司社畜，在奇葩上司叶守愚（淮文 饰演）的“特殊关照”，废柴同事林开心（文生 饰演）的拖后腿，以及大明星温世晴（邱赫南 饰演）的娱乐圈诱惑中，最终学会如何倾听自己的声音，找寻自我人生路的故事。
回复 :Rae is pleased to have the apparently fearless Liam as her best, platonic friend, but is surprised that he wants to keep his group attendance secret. This spells trouble for Rae when Liam's violent girlfriend Amy, said to have been expelled from her last college for assault, threatens her and wants to know why they spend so much time together. She gives her until Friday. Liam refuses to tell Amy the truth but Rae sees he is not so tough when he breaks down and they kiss. Archie is also given the ultimatum by www.2kyb.com Lois to come out by Friday or else she will expose him. He suggests to Rae they run off together but she dissuades him and is pleased when Finn, anxious to resume a non-sexual friendship, offers to teach her self-defence. Come Friday Archie confesses to being gay to generally positive reactions whilst Amy crumbles when Rae tells her she kissed Liam. Back home Mum explains to Rae that she is converting to Islam as Karim, now a lollipop man, wants their baby born into the religion.
